MDMA THERAPY NETHERLANDS

Microdosing vs. Macrodosing

Microdosing, the use of small doses of psychedelics such as LSD or psilocybin, is often promoted as a method for improving mood and enhancing cognitive function. However, recent research suggests that macrodosing may be more effective than microdosing, largely due to the role of monoamine oxidase (MAO) in the breakdown of psychedelic compounds. MAO breaks down neurotransmitters such as serotonin, dopamine, and norepinephrine, as well as psychedelic compounds. When microdosing, psilocybin is broken down rapidly, resulting in minimal effects. This explains why some studies have found no significant benefits over placebo (source).

Higher doses of psychedelics last longer and can have more profound effects on the brain. They stimulate 5-HT₂A receptors, increase glutamate levels, and promote neuroplasticity, which can help treat depression and anxiety. Because macrodosing can produce intense experiences, a safe environment, breathing techniques, and guidance from an experienced therapist are essential tripsitter or therapist highly recommended.

Psychedelic therapies

Psychedelic therapy can be used in various ways and has the potential to alleviate mental and emotional complaints. There are four main forms of psychedelic therapy: individual sessions, group sessions and retreats, microdosing, and integration and aftercare programs (source).

Individual therapeutic sessions focus on personal growth, trauma processing, and improving mental well-being. These sessions are often tailored to specific issues such as depression or anxiety. Group sessions and retreats offer the opportunity to share experiences and work well for people who benefit from collective support and connection. Microdosing, while less intense than macrodosing, can help promote creativity, mood, and focus over a longer period of time. Finally, it is important to process the insights gained after a psychedelic experience and integrate them into daily life. This can be done through coaching, breathing exercises, or therapy.

Psilocybin therapy

Psilocybin is being studied in clinical trials for its potential therapeutic applications. Studies show that psilocybin therapy shows promise in treating treatment-resistant depression, anxiety disorders, and post-traumatic stress disorder (PTSD). In addition, psilocybin is being studied for its potential to help with addictions to alcohol and tobacco, among other things, by reducing cravings and promoting behavioral change.

A psilocybin session consists of three phases: preparation, the session itself and integration. During the preparation, an intake interview is held to assess intentions and medical suitability. During the session, which takes place under the guidance of a therapist or trip sitter, the participant takes psilocybin (often as truffles). The effects begin after 15 to 30 minutes and last for several hours (source). Afterwards, the insights gained are discussed and linked to daily life.

Although psilocybin therapy is not yet a recognized medical treatment and is not reimbursed by health insurers, there are possibilities for guided sessions in the Netherlands. It is expected that psilocybin therapy may be recognized by 2027.

MDMA Retreats

In addition to psilocybin therapy, MDMA retreats are becoming increasingly popular as a method to facilitate deep emotional work. MDMA is known for its empathogenic and therapeutic properties, making it particularly useful for treating trauma and emotional blockages. During an MDMA retreat, which typically lasts two days, participants are given the opportunity to use MDMA to facilitate emotional processing under the guidance of experienced therapists and trip-sitters. The effects of MDMA help to reduce anxiety and increase empathy, making people feel safer to process deeper emotions and memories.

Scientific research suggests that MDMA-assisted therapy can be effective in treating post-traumatic stress disorder (PTSD), anxiety disorders, and depression. It is also used in relationship therapy, as MDMA promotes openness and emotional connection (source).

Conclusion

While microdosing may have benefits, studies suggest that macrodosing has a more powerful effect on neuroplasticity and therapy outcomes. This is due to MAO’s role in the breakdown of psychedelics and its stronger impact on brain connections at higher doses.

Psychedelic therapies such as psilocybin and MDMA offer promising possibilities for treating mental health issues, provided they are used under proper supervision. When using psychedelics, it is important to carefully weigh the balance between benefits and risks.

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